Prenatal developmental toxicity studies of 1,1,1-trichloro-2,2-bis(4-methoxyphenyl)ethane (methoxychlor) in rats and rabbits
نویسندگان
چکیده
منابع مشابه
Historical control data on prenatal developmental toxicity studies in rabbits.
Historical control data on rabbit prenatal developmental toxicity studies, performed between 1994-2010, were obtained from 20 laboratories, including 11 pharmaceutical and chemical companies and nine contract laboratories, in Japan. In this paper, data were incorporated from a laboratory if the information was based on 10 studies or more. Japanese White rabbits and New Zealand White rabbits wer...
متن کاملDevelopmental Toxicity Studies with Atrazine and its Major Metabolites in Rats and Rabbits
Atrazine (ATR), hydroxyatrazine (OH-ATR), and the three chloro metabolites of ATR (deethylatrazine [DEA], deisopropylatrazine [DIA], diaminochlorotriazine [DACT]) were evaluated for developmental effects in rats and rabbits. Three developmental toxicity studies were conducted on ATR in rats (two studies) and rabbits and a developmental toxicity study was conducted in rats for each of the four A...
متن کاملErratum to "Developmental toxicity studies of four fragrances in rats".
The Publisher wishes to appologise that the dosages of HHCB and AHTN were listed incorrectly in the above article. Page 173, left column, lines 11 to 21 should correctly read: Based on estimated maximal daily dermal dosages of 0.11 mg/kg/day of HHCB and 0.043 mg/kg/day of AHTN and 0.025 mg/kg/day of musk ketone and 0.014 mg/kg/day of musk xylene in humans (unpublished industry survey), the mate...
متن کاملDevelopmental toxicity studies of four fragrances in rats.
Four fragrances, 6-acetyl-1,1,2,4,4,7-hexamethyltetraline (AHTN), 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-ben zopyran (HHCB), musk ketone and musk xylene were tested for developmental toxicity in Sprague-Dawley rats (25/group, 3 groups/fragrance, 2 fragrances/corn oil control). Dosages tested were HHCB: 50, 150, 500 mg/kg per day; AHTN: 5, 15, 50 mg/kg per day; musk keton...
متن کاملCarcinogenicity and toxicity of methoxychlor.
Methoxychlor is carcinogenic for the liver of C3H and BALB/c mice and Osborne-Mendel rats, and possibly for the liver of dogs. Methoxychlor is also carcinogenic for the testis of BALB/c male mice, bone of B6C3F1 female mice, and the ovary of Osborne-Mendel female rats. The incidences of carcinomas of the liver were increased in C3H male mice and BALB/c male and female mice fed methoxychlor. The...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Congenital Anomalies
سال: 2001
ISSN: 0914-3505,1741-4520
DOI: 10.1111/j.1741-4520.2001.tb00843.x